| Env Domain | Signal peptide C1 V1 loop |
|---|---|
| HXBc2 Scale | : |10 : |20 : |30 : |40 : |50 : |60 : |70 : |80 : |90 : |100 : |110 : |120 : |130 : |140 : |
| HXBc2 Reference | MRVKE---KYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRM |
| JRFL | ....GIRKN.....----.G.............V.......................................................G....K............Q........................N.K..NATNT..--GSEG |
| ADA | .....--K-................................................................................E..........................................N......V..I.---NSS |
| Env Domain | V2 loop C2 V |
|---|---|
| HXBc2 Scale | |150 : |160 : |170 : |180 : |190 : |200 : |210 : |220 : |230 : |240 : |250 : |260 : |270 : |280 : |290 : |
| HXBc2 Reference | IMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCT |
| JRFL | T..................D.......L............N.....I.........................................K...K..................................D.............KE....... |
| ADA | EGM................D.......L............N.....I.....T..................T.........K..K.......K..................................S.......N.....KE....... |
| Env Domain | 3 loop C3 V4 loop C4 |
|---|---|
| HXBc2 Scale | |300 : |310 : |320 : |330 : |340 : |350 : |360 : |370 : |380 : |390 : |400 : |410 : |420 : |430 : |440 : |
| HXBc2 Reference | RPNNNTRKRIRIQRGPGRAFVTIGK-IGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWS-TEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRC |
| JRFL | ........S.H.--......Y.T..I.......................VI......E-......NH.........M......................N...-----EG..NTEG............................R..... |
| ADA | ........S.H.--......Y.T..I.............T......N..................N..........M......................NF.GTWNLTQ..G................................R..... |
| Env Domain | V5 loop C5 CS Fusion peptide HR1 |
|---|---|
| HXBc2 Scale | |450 : |460 : |470 : |480 : |490 : |500 : |510 : |520 : |530 : |540 : |550 : |560 : |570 : |580 : |590 |
| HXBc2 Reference | SSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVG-IGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLG |
| JRFL | ..............I.E.G..................................................-............................L....................R.......................G...... |
| ADA | ..............T...G..................................................T............................L................................................... |
| Env Domain | HR2 TM domain Cytoplasmic tail |
|---|---|
| HXBc2 Scale | : |600 : |610 : |620 : |630 : |640 : |650 : |660 : |670 : |680 : |690 : |700 : |710 : |720 : |730 : |740 |
| HXBc2 Reference | IWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDR |
| JRFL | ...............................M..............E...................................K......................T...................L..A..................... |
| ADA | ...................................................................................................................................................... |
| Env Domain | |
|---|---|
| HXBc2 Scale | : |750 : |760 : |770 : |780 : |790 : |800 : |810 : |820 : |830 : |840 : |850 : |
| HXBc2 Reference | SIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL* |
| JRFL | .G.....F.....V..................T..............V.......................................A..RTY...L...T........A..- |
| ADA | ..........................................................................................A.Y.................... |